Buet logoBiophysics Research Laboratory
BUET

Sayem photoDr. Mohammad Abu Sayem Karal

Associate Professor
Department of Physics, BUET, Dhaka-1000

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♦♦ Research Area ♦♦

At a Glance ....
Biophysics Research Laboratory mainly deals with artificial lipid membranes synthesis and its characterization. The lipid membranes has been prepared in the form of vesicles. It is also called liposome. Vesicles or liposomes can be categorized into three types depending on their size. It would be giant unilamellar vesicles (GUVs), large unilamellar vesicles (LUVs) and small unilamellar vesicles (SUVs). The size of the GUVs is very similar to real cell and the physiological condition of GUVs is also similar to cell. Therefore, GUVs can be used a artificial cells and the lipid membranes is considered as a mimic of plasma membranes or biomembranes of cells. We also deals with nanoparticles synthesis, characterization and its biological applications. The salient research areas are Membrane Biophysics, Nanotechnology, Medical Physics, Biomedical Physics, Health Physics, Nuclear Physics, Simulation and so on.

biophysics


Biophysics
membrane photo1

Biophysics or biological physics is an interdisciplinary science that applies the approaches and methods of physics to study biological systems. Biophysicists study life at every level, from atoms and molecules to cells, organisms, and environments. As innovations come out of physics and biology labs, biophysicists find new areas to explore where they can apply their expertise, create new tools, and learn new things. The work always aims to find out how biological systems work.
Medical Physics
Brain MRI

Medical physics is the application of physics concepts, theories and methods to medicine or healthcare. Medical Physicists will contribute to maintaining and improving the quality, safety and cost-effectiveness of healthcare services through patient-oriented activities. They optimized clinical use of medical devices and regarding patient risks and protection from associated physical agents (x-rays, electromagnetic fields, laser light, radionuclides) including the prevention of unintended or accidental exposures.
Biomedical Physics
Axial slices through an intervertebral disc of an equine sample

The biomedical physics seeks to understand the role of physical processes occurring on molecular, cellular, or macroscopic scales; ranging from the interaction of chemicals with DNA, to the generation of complex electrical signals in the brain and nervous system; and physical principles of medical devices. It also includes the innovations of hardware and software development whether it can be used for future clinical applications or research in animals and humans.
Nanobiomaterials
Nano Biomaterial

Nanobiomaterials exhibit distinctive characteristics, including mechanical, electrical, and optical properties, which make them suitable for a variety of biological applications. Because of their versatility, they play a central role in nanobiotechnology and make significant contributions to biomedical research and healthcare. Novel approaches for bottom-up and top-down processing of nanostructured biomaterials are highlighted.
Bioinstrumentation
Bioinstruments

Bioinstrumentation is the use of bioelectronic instruments for the recording or transmission of physiological information. Biomedical devices are an amalgamation of biology, sensors, interface electronics, microcontrollers, and computer programming, and require the combination of several traditional disciplines including biology, optics, mechanics, mathematics, electronics, chemistry, and computer science. Bioinstrumentation teams gather engineers that design, fabricate, test, and manufacture advanced medical instruments and implantabe devices into a single, more productive unit.

Artificial Membrane
Vesicle

Artificially synthesized lipid membranes of thickness about 4 nm are considered as the mimic of biomembranes of cells. The size (diameter 10 micrometer or more) of the giant unilamellar vesicles (GUVs) of lipid membranes is considered to be the similar size of living cells. Therefore, GUVs can be used for various purposes of biomedical research and applications. Here, we prepared the GUVs of lipid membranes using neutral lipid dioleoylphosphatidylcholine (DOPC) and a mixture of negatively charged lipid dioleoylphosphatidylglycerol (DOPG) and DOPC using natural swelling method. The size of the GUVs was found in the range of 10-85 micrometer